As global attention surrounding the pandemic wanes, its lingering effects continue to impact the health of millions. Physical and mental fatigue, low energy, joint pain, high stress levels, circulatory and cardiac problems, as well as memory lapses and mental confusion, continue to increase and exacerbate pre-existing conditions such as obesity and hyperglycemia.

Health professionals call this set of symptoms post-COVID syndrome or long COVID. Increasingly, experts emphasize that prevention and continuous monitoring are essential pillars for long-term well-being, complementing a balanced lifestyle.

A clear example of this scenario is that of Mrs. Creusa, 82 years old, mother of integrative therapist Dr. Leonardo Bear. After the pandemic, Creusa began to experience intense fatigue, unwanted weight gain, uncontrolled glucose levels, and a visible worsening of blood circulation—factors that directly affected her energy, vitality, and quality of life.

Motivated by his mother's fragile health and aware of the risks of her advanced age, Dr. Bear knew that waiting for science wasn't an option. Time was a luxury he didn't have. As a therapist passionate about nutrition—but above all, as a son—he decided to act. His goal was clear: To find a natural formula capable of strengthening immunity and promoting health in the most affected areas of your mother's body.

He wasn't looking for a miracle cure, but rather a real hope for improvement. And then... Studies shed some light on the situation.

Health

Policy

World

Persistent symptoms such as fatigue and memory lapses still affect millions of people worldwide after the pandemic.

Health

Trecho do estudo da NHI (PMCID: PMC9709252 PMID: 36466841| PMCID: PMC11465292 PMID: 39391859). THE MAGAZINE OF HARVARD MEDICAL SCHOOL

In most people—especially those who are vaccinated—COVID-19 manifests with flu-like symptoms that disappear within a few days or weeks. But in some cases, the disease progresses to a more dangerous phase: the so-called cytokine storm, when the immune system becomes hyperactive and causes severe inflammation.

According to experts, at this stage patients can develop heart muscle weakness, low oxygen levels, blood clots, and even fluid in the lungs—problems that often require hospitalization.

Other studies by the NHI also confirm that post-COVID fatigue is common and can persist for months. It results from organ damage, impacts on mental health, or systemic inflammation that affects the body's circulation and energy.

This was exactly what was confirmed in the case of Dr. Bear's mother regarding blood circulation. However, the chronic fatigue and memory lapses did not disappear over time—perhaps due to her advanced age, since in 2020 she was 78 years old. Now, however, Leonardo had scientific evidence that the cause was so-called long COVID.

These studies offered some direction: Although there was no definitive treatment, the alternative was to seek a supplement capable of relieving the symptoms or, at least, contributing to improving their health and quality of life.

But then… what was obvious ended up happening.

There were no supplements capable of meeting my mother's specific needs. The available products were incomplete: the multivitamins were all the same, and the immune supplements were generic. Finding something truly promising was impossible.

Even with the specialized knowledge that most people don't possess, it would be necessary to acquire several different products—and even then, essential components would be missing. Furthermore, because of the very similar formulas, some ingredients ended up appearing in excess, while others were simply absent.

It was clear: the market did not offer a viable, personalized, and effective alternative.

What she needed was not just a common supplement. She needed something special, unique, and specific, capable of acting on several fronts at the same time:

  • Antioxidants and anti-inflammatories → to fight free radicals and reduce chronic inflammation.

  • Metabolism activation → to stimulate daily energy and vitality.

  • Mitochondrial biogenesis → to promote the creation of new mitochondria, increasing cellular energy efficiency.

  • Neuroprotection → to protect neurons, improve memory, and sharpen focus.

  • Immunomodulation → to balance and strengthen the immune system.

  • Induction of autophagy → to promote cell renewal and longevity.

  • Increase of glutathione → to boost the body’s most powerful natural antioxidant.

  • Vasodilation and nitric oxide modulation → to improve circulation and vascular health.

  • Fibrinolytic action → to help reduce the risk of blood clots and support cardiovascular well-being.

Conclusion: It couldn't just be another supplement. It needed to be a complete formula, developed with the necessary components to meet the challenges of our new post-pandemic reality.

“That’s when I saw the opportunity of a lifetime. Unfortunately—and ironically—in my mother’s pain and suffering, I found a light. Not only to help my dear mother, but also for the life of my family. That’s how BEAR NUTRITION LABS was born and, with it, its first premium product: IMMUNOBEAR®.”

But Dr. Bear wasn't content with just positive results. He wanted more. He wanted something that went beyond a supplement, capable of enhancing the effects and preparing the body and mind for a true health journey.

And then… something incredible happened.

Outdated industry

In his own words, Dr. Leonardo Bear summarizes a perception that changed the course of his research:

“Our studies revealed a growing dissatisfaction with the isolated results of conventional methods. Often, the challenge lies not only in the approach itself, but also in how the body and mind are (or are not) prepared to absorb what is offered.”

This vision led to the creation of IMMUNOGUIDE®, an innovative development program designed to provide complete preparation — physical, mental, nutritional, and social. It was conceived to precede the launch of the brand’s first product, with the goal of supporting individuals in their recovery, regardless of age, mobility, or limitations, and preparing the body for any treatment.

The role of IMMUNOGUIDE® goes beyond preparing the body and mind to maximize the benefits of a product: it enhances its effects in a synergistic and conscious way. More than just a support tool, it was created to amplify the results of any intervention, becoming a true ally in the journey toward metabolic balance and lasting well-being.

“More than just a preparation tool, IMMUNOGUIDE® is a practical and empowering methodology based on a unique therapeutic philosophy we call THE BEAR KING. The central idea is to rebuild the human ecosystem, encouraging inner balance through a holistic focus on body, mind, and lifestyle.” — Dr. Leonardo Bear

“Our mission is to help people reconnect with their natural balance, creating a stronger foundation for personal well-being and resilience.” — Dr. Leonardo Bear

The Four Pillars of IMMUNOGUIDE®

The IMMUNOGUIDE® program presents strategies based on a universal logic of preparation, designed to help people address persistent wellness challenges. Created to support the body and mind through a holistic perspective, the program encourages greater awareness and proactive engagement with personal well-being.

Structured around four interconnected pillars, IMMUNOGUIDE® offers a comprehensive framework for cultivating resilience:

  • Physical: Movement, strength, and conditioning practices that encourage vitality and physical response.

  • Nutritional: Approaches to gut health, detoxification, and conscious supplementation to help maintain internal balance.

  • Psychological: Tools for emotional regulation and mental clarity to better manage stress and foster resilience.

  • Social: Strategies to strengthen connection, reduce isolation, and promote community engagement and self-sufficiency.

"IMMUNOGUIDE® is more than a program — it's a mindset. By addressing multiple dimensions of human well-being through its four pillars, it offers a practical and empowering path toward long-term balance. Whether reflecting on past challenges or preparing for future ones, IMMUNOGUIDE® invites you to rebuild your internal ecosystem with intention, awareness, and care."

"Because true well-being is not just the absence of discomfort — it is the presence of strength, clarity, connection, and vitality."

Limited Global Pre-Launch.

Quality, Exclusivity, and Innovation: This is the Essence of BEAR NUTRITION LABS

At BEAR NUTRITION LABS, we believe in a universal truth: everything truly valuable is scarce and exclusive. Therefore, we are not just launching a product—we are introducing a new way to take care of your health by innovating in our relationship with the customer.

We are proud to launch two milestones:

IMMUNOGUIDE® — an exclusive method to support the rebalancing of the human ecosystem.

But, more than that, we want to revolutionize the way we sell. We call this the EXCLUSIVE PURCHASE: our products will be available only to selected members, ensuring a more personalized shopping experience, with special benefits and unique resources.

First Call: Limited Initial Batch

The first spots are now open for the initial wave of the IMMUNOGUIDE® pre-launch experience. This group will be limited to just 10,000 participants—and only these people will have:

✅ Guaranteed right to purchase IMMUNOBEAR®, scheduled for launch in April 2026

✅ Access to the BEAR NUTRITION LABS members' club, with priority on purchasing future launches

✅ Exclusive wellness experience, with early access and special content

If you value innovation and exclusivity, this is your opportunity to be part of something truly transformative.

If this feels right for you—and if your health is truly important to you—click below and discover what is transforming my family's life... and can become your ally too.

A discovery from the National Institutes of Health (NIH) and Harvard.

"This is the reason behind the product — and having my mother still with me, healthy and recovered, is my greatest victory."

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"Rebuilding the Human Ecosystem” – The knowledge that led to the creation of a preparation before the use of any product.

Therapist Leonardo Bear already knew exactly where and how a supplement should act. It was the best alternative until science could offer definitive answers. However, even with the positive results that IMMUNOBEAR® brought to his mother, he wasn't satisfied.

Because it was not a medication or a scientifically conclusive treatment, Leonardo understood he needed to increase the effectiveness of his product. Although he had created something unique, he recognized the limitations of supplements. Still, he knew there was no better or more complete formula than the one he had developed. His mission was clear: to design a method capable of promoting health while respecting individual limitations and the challenges faced by the elderly and those with reduced mobility.

It was in this context that a true philosophy of life and health was born. In Dr. Bear’s own words:

“Health does not come only from medications or supplements; it arises mainly from awareness, preparation, execution, and consistency in preventive and corrective processes. Health is not a finish line, it is a journey.”

During the development of the formula aimed at supporting the immune system, he realized something essential: any wellness strategy only becomes meaningful when both body and mind are supported in their natural state of balance.

This insight gave rise to the concept of “Rebuilding the Human Ecosystem,” which evolved into a comprehensive awareness and training program he named IMMUNOGUIDE®.

In this program, Dr. Bear demonstrates what is truly necessary to achieve complete bodily balance. As a therapist, he addresses not only the psychological dimension but also the nutritional and physical aspects, emphasizing the importance of multidisciplinary integration. For him, only through this synergy can the body reach full equilibrium.

Leonardo explains with a powerful metaphor:

“For the body to be fertile and receptive, it must be prepared, just as a farmer prepares the soil before planting.”

Thus, IMMUNOGUIDE® was created with a clear purpose: to promote health for everyone — with or without excess weight, with or without mobility limitations, younger or older. It is a preventive and holistic approach, capable of restoring the balance between body and mind, often weakened by modern routines, stress, poor eating habits, and a sedentary lifestyle.

Customer reviews of IMMUNOGUIDE

My wife bought it for me, I don't have the patience to study, but I'm following what she learned in the course and the results are great, I feel much better.

Renato - Concierge agent 45 years old

Absolutely delighted with my purchase! Excellent product, great knowledge and overall a great shopping experience.

Ronaide - Psychologist 40 years old

★★★★★
★★★★★

Of course, I couldn't help but share the most personal reason behind the creation of IMMUNOBEAR: my mother.

I won't publish her testimonial — after all, like any good mother, she would only have praise. But what I can say with complete honesty is that, after applying the IMMUNOGUIDE techniques and starting to use our health protocol with IMMUNOBEAR, her health has improved considerably, especially in aspects related to vitality, disposition and general well-being.

Creusa - retired 82 years old

★★★★★

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Scientific references

[Management of patients with lymphatic diseases and lipoedema during the COVID-19 pandemic. Recommendations of the Spanish Group of Lymphology]

https://pubmed.ncbi.nlm.nih.gov/32863012/

  • PMID: 32863012

  • PMCID: PMC7414319

  • DOI: 10.1016/j.rh.2020.07.003

Pathophysiological mechanisms of thrombosis in acute and long COVID-19

https://pmc.ncbi.nlm.nih.gov/articles/PMC9709252/

PMCID: PMC9709252 PMID: 36466841

https://pmc.ncbi.nlm.nih.gov/articles/PMC11465292/

Recent Updates on COVID-19 Associated Strokes

https://pmc.ncbi.nlm.nih.gov/articles/PMC11465292/

PMCID: PMC11465292 PMID: 39391859

Relationship between Hyperlipidemia, Cardiovascular Disease and Stroke: A Systematic Review

https://pmc.ncbi.nlm.nih.gov/articles/PMC8950504/

PMCID: PMC8950504 PMID: 33305711

COVID-19 and Cardiovascular Disease: A Comprehensive Review

https://pubmed.ncbi.nlm.nih.gov/35704865/

PMID: 35704865

COVID’s Damage Lingers in the Heart

https://magazine.hms.harvard.edu/articles/covids-damage-lingers-heart

Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2

https://pmc.ncbi.nlm.nih.gov/articles/PMC9458005/

PMCID: PMC9458005 PMID: 36080170

I. References on Resistin and Metabolic Risk

These references support the idea that resistin is a harmful hormone linked to insulin resistance and health risks.

Resistin as a risk factor for all-cause (and cardiovascular) death in the general population

• URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC9666658/

• Relevance: Confirms that resistin is a risk factor for overall and cardiovascular mortality, reinforcing its role as a "villain".

The Role of Resistin in Macrovascular and Microvascular Complications of Type 2 Diabetes

• URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC12028410/

• Relevance: Associates resistin with the development and progression of type 2 diabetes complications.

Leptin, resistin, and visfatin: the missing link between endocrine metabolic disorders and immunity

• URL: https://eurjmedres.biomedcentral.com/articles/10.1186/2047-783X-18-12

• Relevance: Confirms resistin as an adipokine linked to metabolic disorders and insulin resistance.

II. References on Mitochondrial Dysfunction and Obesity (Including Harvard)

These references support the idea that obesity causes mitochondrial dysfunction, the body's "broken engine."

Newly discovered mechanism of mitochondrial dysfunction in obesity may drive insulin resistance and type 2 diabetes

• URL: https://hsph.harvard.edu/news/newly-discovered-mechanism-of-mitochondrial-dysfunction-in-obesity-may-drive-insulin-resistance-and-type-2-diabetes/

• Relevance: Study from the Harvard T.H. Chan School of Public Health that identifies a mechanism of mitochondrial dysfunction (excessive ROS production) in obesity, providing Harvard's authority for its narrative.

Mitochondrial Health Markers and Obesity-Related Health in Human Population Studies: A Narrative Review of Recent Literature

• URL: https://pubmed.ncbi.nlm.nih.gov/39287712/

• Relevance: Review summarizing the evidence that altered mitochondrial functions contribute to obesity.

Research | The Sinclair Lab (Harvard Medical School)

• URL: https://sinclair.hms.harvard.edu/research

• Relevance: Demonstrates that Harvard Medical School actively researches mitochondrial function and its relationship to diseases such as Type 2 Diabetes, reinforcing the credibility of its narrative.

III. References on the Unique Mechanism (Resistin vs. Mitochondria)

These references are the most important, as they establish the direct relationship between Resistin and mitochondrial dysfunction, its "unique mechanism".

Resistin destroys mitochondrial biogenesis by inhibiting the PGC-1α/NRF1/TFAM signaling pathway

URL: https://www.sciencedirect.com/science/article/pii/S0006291X18317017

Relevance: Evidence that resistin reduces the number of mitochondria (mitochondrial biogenesis) by inhibiting the "master builder" (PGC-1α).

Resistin impairs mitochondrial homeostasis via cyclase-associated protein 1-mediated fission, leading to obesity-induced metabolic diseases

URL: https://www.sciencedirect.com/science/article/pii/S0026049522002219

Relevance: Evidence that resistin breaks down and fragments mitochondria (abnormal fission), making them dysfunctional.

IV. Additional Reference (Context)

Leukocyte mitochondrial DNA copy number, anthropometric indices, and weight change in US women

URL: https://pubmed.ncbi.nlm.nih.gov/27367031/

  • The Long-Term Cardiovascular Impact of COVID-19: Pathophysiology, Clinical Manifestations, and Management

PMCID: PMC11384648 PMID: 39258051

Cureus

. 2024 Aug 10;16(8):e66554. doi:10.7759/cureus.66554

The Long-Term Cardiovascular Impact of COVID-19: Pathophysiology, Clinical Manifestations, and Management - PMC

URL:https://pmc.ncbi.nlm.nih.gov/articles/PMC11384648/

https://www.sciencedirect.com/science/article/pii/S2352906724001489

Newly detected diabetes during the COVID-19 pandemic: what have we learnt?

Newly detected diabetes during the COVID-19 pandemic: what have we learnt? - PMC

10.1016/j.beem.2023.101793

PMCID: PMC10303323 PMID: 37468405

The enduring effect of the COVID-19 pandemic on diabetes

https://www.thelancet.com/journals/landia/article/PIIS2213-8587(24)00180-3/fulltext

A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on

https://pmc.ncbi.nlm.nih.gov/articles/PMC9107388/

10.1016/j.metabol.2022.155217

PMCID: PMC9107388 PMID: 35584732